To summarize the first aid and nursing experience of an ICU patient with stress cardiomyopathy after kidney transplantation. Nursing points:focus on changes in the condition and implement efficient first aid measures; rapid and accurate assessment,safe and stable transport;strict hemodynamic measurement,goal-oriented fluid management;precise drug administration,observation of drug effects and adverse reactions; emphasis on psychological counseling and rehabilitation training and doing a good job of continuous nursing are keys to the smooth transfer of patients. After careful treatment and care,the patient was transferred to the kidney transplant ward for continuous specialist treatment on the 16th day after the operation. On the 38th day after the operation,he recovered and was discharged from the hospital.